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KMID : 0377619730240020191
Korean Jungang Medical Journal
1973 Volume.24 No. 2 p.191 ~ p.195
A Study on Furamido benzothiazole Derivatives


Abstract
The discovery of antibacterial and anti fungal activity in 2, 6-disubstituted benz othiazoles and furane derivatives ¢¥ suggested that some more new antimicrobial substances may also be found from the benzothiazole derivatives possessing furoyl group.
In order to find newer benzothiazole derivatives possessing antibacterial and antifungal activity, fourteen new 2-furamido-6-substituted benzothiazoles were synthesized and evaluated for their antibacterial activity against staphylococcus
aureus, (¥â-strepto coccus and Escherichia coli. These compounds generally showed strong growth-inhibitory activity against (¥â-streptococcus, and some of compounds (VIII, IX, X, VIV) showed growth inhibition against staphylococccus aureus in 10 pg/ml concentration.
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